Photoredox radical conjugate addition of dithiane-2-carboxylate promoted by an iridium(iii) phenyl-tetrazole complex: a formal radical methylation of Michael acceptors.

Photoredox radical conjugate addition of dithiane-2-carboxylate promoted by an iridium(iii) phenyl-tetrazole complex: a formal radical methylation of Michael acceptors† †Electronic supplementary information (ESI) available: Experimental procedures, product characterizations, NMR spectra, compound preparation procedures, screening tests, and photophysical and electrochemical data. See DOI: 10.1039/c6sc03374a Click here for additional data file.

A highly selective and sensitive ratiometric chemodosimeter for Hg2+ ions based on an iridium(III) complex via thioacetal deprotection reaction.

A novel luminescent biscyclometalated iridium(III) complex [Ir(C^N)2bpy]PF6 (Ir-S, bpy = 2,2'-bipyridine) containing two 2-phenylpyridine (ppy) cyclometalating ligands (C^N) functionalized with 1,3-dithiane for the detection of Hg(2+) ions has been synthesized and characterized by spectroscopic and photophysical measurements. The luminescence of Ir-S exhibits a ratiometric response upon the add...

Carboxylic Acids as A Traceless Activation Group for Conjugate Additions: A Three-Step Synthesis of (±)-Pregabalin

The direct application of carboxylic acids as a traceless activation group for radical Michael additions has been accomplished via visible light-mediated photoredox catalysis. Photon-induced oxidation of a broad series of carboxylic acids, including hydrocarbon-substituted, α-oxy, and α-amino acids, provides a versatile CO2-extrusion platform to generate Michael donors without the requirement f...

Oxidative Radical Cyclization–Cyclization Reaction Leading to 1H-Benzo[f]isoindole Derivatives

The synthesis of 1H-benzo[f ]isoindole derivatives was achieved by the cascade radical cyclization–cyclization reaction of the active methine substrate having an allyl group and phenyl group as different two radical acceptors. This oxidative transformation proceeded by using iron(III) chloride FeCl3 as a mild oxidant via the intramolecular radical addition to the allyl group followed by the sec...

A lab-on-a-molecule for anions in aqueous solution: using Kolbe electrolysis and radical methylation at iridium for sensing.

Iridium complex [(pq)(2)IrCl](2) (1) is established as a quantitatively operating lab-on-a-molecule in aqueous media at physiological pH. Acting as a chemodosimeter, 1 uses two channels, PL and ECL, for the detection of cyanide and acetate, with the former undergoing nucleophilic attack and the latter Kolbe electrolysis and radical-metal combination.